Product name Nicotinamide riboside chloride powder
Synonyms 3-(Aminocarbonyl)-1-P-D-ribofuranosyl-pyridinium chloride(1 :1);Nicotinamide
Riboside.Cl;3-Carbamoyl-1-beta-D-ribofuranosyl-pyridinium chloride; NR, vitamin NR;
CAS Number 23111-00-4
Molecular formula C11H15CIN2O5
Molecular weight 290.70 g/mol
Appearance/Color Off White to Pale Yellow Powder
Solubility in water 446.5mg/ml
Melting point 115℃-125℃
Benefits Boosts NAD+ levels, Supports healthy Aging and brain/cognitive
Applications as a dietary supplement, functional foods, and beverages
Nicotinamide Riboside Chloride is a crystal form of Nicotinamide riboside (NR) chloride termed NIAGEN, generally recognized as safe (GRAS) for use in foods and in dietary supplements. Nicotinamide Riboside Chloride is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside is a newly discovered NAD (NAD+) precursor vitamin.
Nicotinamide Riboside is an NAD+ precursor. It is a substrate for nicotinamide riboside kinases (NRK1/2). Nicotinamide Riboside shows neuroprotective effects in a mouse model of type 2 diabetes and improves mitochondrial function in muscle stem cells in aged mice. The compound also corrects non-alchoholic fatty liver disease phenotype induced by NAD+ deficiency or high-fat diet in mice. Orally bioavailable.
If you are trying to decide between our NR and NMN, then we need to look at where each one excels. NMN seems to take the lead when we consider purely its NAD+ elevating effects, however, NR does something quite unique! NR itself appears to be quite neuroprotective, independent from its ability to increase NAD+ levels. So, if you are looking for the most neuroprotective NAD+ precursor, then NR is the one for you!
Nicotinamide riboside (NR) is a naturally occurring Vitamin B3 (niacin) derivative whose main purpose is often to be converted into either nicotinamide adenine dinucleotide (NAD+), nicotinamide (NAM) or even NMN! NR is mostly absorbed in the liver where it then begins its journey to being converted into either NAD+, NAM or NMN. There are many different foods and drinks that naturally contain NR, but at nowhere near the levels we can achieve with supplementation!
Nicotinamide Riboside Benefits & Uses
Promotes NAD+ levels
Promote cellular energy
Promotes brain health
NR for NAD+ Creation
Nicotinamide riboside is very well researched for its function as an NAD+ precursor and is seen as one of the best ways in which to increase NAD+ levels! NAD+ plays a major role in energy production, balancing oxidation levels, metabolic function and more! Although NR isn’t the only precursor option for NAD+, it is often thought to be one of the more stable options for long-term NAD+ production and for brain specific effects.
In addition to NAD+, NR also functions as a precursor to NMN and nicotinamide (NAM). NAM helps to promote cardiovascular function while NMN promotes balanced oxidation levels and cellular function, while also acting as another highly efficient NAD+ precursor. In fact, for NR to produce NAD+, it first has to be converted to NMN! With this in mind it is then quite clear that the reason these compounds are created from NR, is due to the fact that NMN and NAM both participate in the same cycle through which NR produces NAD+.
NR For Neuroprotection
One of NR’s claims to fame is its neuroprotective effects. This is also where NR seems to be more specialized when compared to NMN, another highly effective NAD+ precursor. This likely has to do with the fact that NR supplementation can directly affect NR related pathways in axons of neurons, where it can then locally produce fairly high levels of NAD+. Having higher levels of NAD+ in axons appears to be a fantastic neuroprotective strategy.
Things get a little bit more interesting when we really dive into the research behind NR’s neuroprotective effects though. It appears that NR itself is producing some of these neuroprotective effects, as NR seems to be more neuroprotective when compared to NAD+ itself. This further points to the fact that NR is the best NAD+ precursor to take if neuroprotection is one of your main goals!